Scheduling Nab-paclitaxel With Gemcitabine

Inclusion Criteria

• •Aged ≥ 18 years old
• •Signed informed consent and ability to comply with the protocol
• •Histologically or cytologically confirmed metastatic PDAC
• •Radiologically confirmed stage IV disease and measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1; baseline tumour assessments and measurements must be done within 28 days prior to randomisation
• •Karnofsky performance status ≥70%
• •Life expectancy \>12 weeks from the date of screening assessment
• •Adequate bone marrow function
• •* Absolute neutrophil count (ANC) ≥1.5 x 109 /L
• •* Haemoglobin (Hb) ≥ 100 g/L
• •* Platelets ≥100 x 109 /L
• •* White blood cell count (WBC) ≥ 3 x 109 /L
• •Adequate liver function
• •* Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) ≤2.5 x upper limit of normal range (ULN)
• •* Total bilirubin \<1.5 x ULN
• •Adequate renal function defined as a serum creatinine ≤1.5 x ULN or calculated creatinine clearance by Cockcroft-Gault of ≥50 mL/min
• •Received no prior systemic therapy for metastatic disease
• •Prior adjuvant chemotherapy (with GEM or any other drug/s) is allowed if completed at least 6 months previously
• •Prior radiotherapy is allowed as long as there is measurable disease which has not been irradiated
• •Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, completion of QoL and HE questionnaires and other study procedures
• •Confirmation of tumour tissue sample collected within 12 weeks prior to randomisation and blood to be taken prior to randomisation
• •Women of child-bearing potential (WCBP), defined as a sexually mature woman not surgically sterilized or not post-menopausal for at least 24 consecutive months if age ≤55 years or 12 months if age \>55 years, must have a negative serum or urine pregnancy test within 14 days prior to randomisation
• •All WCBP and all sexually active male patients must agree to use effective contraception methods throughout the study and for 30 days after the final dose of study drug for WCBP and for up to 6 months after treatment for male patients