Clinical Study of Lipoic Acid on Ischemic Heart Failure

Exclusion Criteria

• •Use of other investigational drugs at the time of enrollment, or within 30 days or 5 half-lives of enrollment, whichever is longer.
• •* allergy to any of the study drugs, drugs of similar chemical classes（Vitamin B） as well as known or suspected contraindications to the study drugs.
• •* Previous history of intolerance to recommended target doses of α-LA.
• •* Current acute decompensated HF (exacerbation of chronic HF manifested by signs and symptoms that may require intravenous therapy).
• •⑤ Symptomatic hypotension and/or a SBP \< 100 mmHg.
• •⑥ Severe liver function abnormalities (ALT or AST more than 3 times of the normal upper limit).
• •⑦ Estimated GFR \< 30 mL/min/1.73m2 as measured by the simplified MDRD formula.
• •⑧ Serum potassium \> 5.2 mmol/L.
• •⑨ Pregnant women or women preparing for birth.