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Collection of Bone Specimens for Quantitative Analysis of Global Proteome and Iron Content Detection
RATIONALE: Collecting and storing bone samples from patients with osteoporotic and nonosteoporotic fracture to quantitatively analyze the differentially expressed proteins to further explain the relationship between bone iron content and bone mineral density (BMD). PURPOSE: This research study is looking at changes of iron content and differentially expressed proteins in bone samples from patients with osteoporotic and nonosteoporotic. fracture.
OBJECTIVES: 1. Establish the iron content in bone specimen in patients with hip fracture. 2. Explore the correlation of BMD and differentially expressed proteins. OUTLINE: 1. Collect human bone specimens from patients with osteoporotic and nonosteoporotic Fracture. 2. Provide a repository for storage of tissue and make these specimens available for approved projects by laboratory-based investigators. 3. Collect clinical data on these patients including bone mineral density. 4. To examine the bone iron content using ICP/MS. 5. Investigate the differentially expressed proteins through quantitative analysing the global proteome of osteoporotic and nonosteoporotic fracture bone specimens.
Age
55 - 90 years
Sex
FEMALE
Healthy Volunteers
No
Second Affiliated Hospital of Soochow University
Suzhou, Jiagnsu, China
Start Date
April 1, 2018
Primary Completion Date
January 1, 2019
Completion Date
May 1, 2019
Last Updated
February 12, 2018
100
ESTIMATED participants
total hip arthroplasty
PROCEDURE
Lead Sponsor
Second Affiliated Hospital of Soochow University
NCT06565910
NCT07442721
Data Source & Attribution
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