Study of Ketamine for Depression in Cancer Patients Receiving Palliative Care

Inclusion Criteria

• •Provide written, voluntary informed consent prior to study enrollment. Participants must be capable of consenting to treatment as substitute decision makers will not be allowed to consent to the study on their behalf
• •Males and females ≥ 18 years of age
• •Patient is receiving palliative care at Princess Margaret Cancer Centre (PM) including all in-patient units and outpatients
• •Meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for Major Depressive Disorder (MDD), with a current Major Depressive Episode (MDE)
• •Depression severity must be in the moderate to severe range, as determined by a Montgomery-Åsberg Depression Rating Scale (MADRS) score greater than or equal to 20
• •Participants must have a confirmed diagnosis of cancer and an estimated life expectancy of less than twelve months, as determined by the palliative care physician