Icotinib Combined With Dihydroaremisinin (DHA) Therapy in Patients With Advanced NSCLC

Icotinib Combined With Dihydroaremisinin (DHA) Therapy in Patients With Advanced Gradually Progressed NSCLC After First-line Icotinib: an Open-label, Single-arm, Multicenter Phase II Study

NCT03402464•Peking University Cancer Hospital & Institute

View on ClinicalTrials.gov

Summary

The study was to evaluate the safety, PFS and ORR of icotinib/dihydroaremisinin (DHA)-based combination therapy in EGFR-mutated, advanced NSCLC patients who have gradually progressed disease after first-line icotinib treatment.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Patients confirmed with stage IV lung adenocarcinoma by pathologic histology or cytology who can't accept surgery and radiotherapy
•2. Male or female patients aged ≥18 years, life expectancy ≥ 12 weeks
•3. Eastern Cooperative Oncology Group (ECOG) performance status 0-2
•4. Sensitive EGFR gene mutation(19/21)
•5. Failed with first-line icotinib and have gradually progressed disease More than 6-month duration of first-line icotinib (from the first dosing to the imaging-confirmed progression; and discontinuation of icotinib is less than 14 days) No significantly increased tumor size compared with the final imaging evaluation

Exclusion Criteria

•1. Any unstable systemic disease (including active infection, uncontrolled hypertension, unstable angina, congestive heart failure, myocardial infarction within the previous year, serious cardiac arrhythmia requiring medication, hepatic, renal, or metabolic disease)
•2. Female subjects should not be pregnant or breast-feeding
•3. Patient assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol
•4. Previous systemic anti-tumor therapy except for icotinib , including chemotherapy or targeted therapy ( including but not limited to monoclonal or antibodies, small molecule tyrosine kinase inhibitor, etc)
•5. Tumor metastasis of the spinal cord, meninges or meningeal neoplasms confirmed by imaging or cerebrospinal fluid examination

Locations (1)

Beijing Cancer Hospital

Beijing, China

Key Dates

Start Date

January 1, 2018

Primary Completion Date

June 1, 2019

Completion Date

September 20, 2020

Last Updated

January 18, 2018

Enrollment

ESTIMATED participants

Conditions

EGFR Positive Non-Small Cell Lung Cancer,Adenocarcinoma

Interventions

Icotinib combined dihydroaremisinin

DRUG

Contacts

Ziping Wang, MD

CONTACT

86-10-88121122 wangzp2007@126.com