Clinical Study of ET1402L1-CAR T Cells in AFP Expressing Hepatocellular Carcinoma

Exclusion Criteria

• •Patients with decompensated cirrhosis: Child-Pugh Score C
• •Patients with an organ transplantation history
• •Patients with tumor infiltration in the portal vein, hepatic veins or inferior vena cava that completely blocks circulation in liver.
• •Patients with dependence on corticosteroids
• •Patients with active autoimmune diseases requiring systemic immunosuppressive therapy
• •Patients who are currently receiving or received within past 30 days anti-cancer therapy, local treatments for liver tumors (radiotherapy, embolism, ablation) or liver surgery
• •Patients currently receiving other investigational treatments (biotherapy, chemotherapy, or radiotherapy)
• •Patients undergoing current treatment known to interfere with lymphodepleting chemotherapy (cyclophosphamide, etc.).
• •Participants with other active malignancies (except non-melanoma skin cancer and cervical cancer) within two years. Patients with a history of successfully-treated tumors with no sign of recurrence in the last two years may be enrolled.
• •Patients with other uncontrolled diseases, such as active infections:
• •* Acute or chronic active hepatitis B or hepatitis C.
• •* HIV-infection
• •Women who are pregnant