Contrast-Enhanced Subharmonic Ultrasound Imaging in Improving Characterization of Adnexal Masses in Patients Undergoing Surgery

Exclusion Criteria

• •Females who are pregnant or nursing
• •Patients who have received an investigational drug in the 30 days before study drug administration, or will receive one within 72 hours (h) afterwards
• •Patients with known or suspected right-to-left, bi-directional, or transient right-to-left cardiac shunts
• •Patients with pulmonary hypertension or unstable cardiopulmonary conditions
• •Patients currently on chemotherapy or with other primary cancers requiring systemic or hepatic loco-regional treatment
• •Patients who are clinically unstable, patients who are seriously or terminally ill with a life expectancy of less than 1 month, and patients whose clinical course are unpredictable; for example:
• •* Patients on life support or in a critical care unit
• •* Patients with unstable occlusive disease (e.g., crescendo angina)
• •* Patients with clinically unstable cardiac arrhythmias, such as recurrent ventricular tachycardia
• •* Patients with uncontrolled congestive heart failure (New York Heart Association \[NYHA\] class IV)
• •* Patients with recent cerebral hemorrhage
• •* Patients who have undergone surgery within 24 hours prior to the study sonographic examination
• •Patients with a history of anaphylactic allergy to Definity, manifested by one or more of the following symptoms: generalized urticaria, difficulty in breathing, swelling of the mouth and throat, hypotension, or shock
• •Patients with congenital heart defects
• •Patients with severe emphysema, pulmonary vasculitis, or a history of pulmonary emboli
• •Patients with respiratory distress syndrome
• •Patients with thrombosis within the splenic vein