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Randomized Phase II Trial of Pemetrexed Plus Vinorelbine Versus Vinorelbine in Patients With Recurrent or Metastatic Breast Cancer Previously Treated With or Resistant to Anthracycline and Taxane
Pemetrexed is a multi-targeted anti-folate, that is used for non-small cell lung cancer and mesothelioma. There are several clinical studies of pemetrexed in breast cancer, but these are largely done before the wide use of premedication (steroid and vitamin B12) for pemetrexed. Moreover, it has not been studied in combination with vinorelbine, which is a commonly used drug for anthracycline- and taxane-pretreated metastatic breast cancer. This is a randomized phase II study of pemetrexed plus vinorelbine versus vinorelbine in patients with recurrent or metastatic breast cancer previously treated with or resistant to an anthracycline and taxane.
Age
20 - No limit years
Sex
ALL
Healthy Volunteers
No
Seoul National University Hospital
Seoul, Seoul, South Korea
Start Date
February 17, 2017
Primary Completion Date
December 5, 2023
Completion Date
April 15, 2024
Last Updated
April 17, 2025
17
ACTUAL participants
Pemetrexed + Vinorelbine
DRUG
Vinorelbine
DRUG
Lead Sponsor
Seoul National University Hospital
NCT07191730
NCT06797635
Data Source & Attribution
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