Influence of a Food Supplement on the Gut Microbiome in Healthy Obese Women

Intervention: Variation of the gut microbiome via intake of an herbal yeast preparation. Participants: healthy obese women between 25 and 35 years. Intervention to be studied: Intake of Strath® Kräuterhefe Original (liquid), Herbal Yeast Food Supplement over 3 weeks, stool analysis. Sequence and duration of all study periods: 7 weeks per proband. Week -4 - -2: Pre-Phase Hand out study information First check of inclusion/exclusion criteria Week -2: Initiation-Phase Signed "Informed Consent" Second check of inclusion/exclusion criteria Complete assessment Part I, II (see 8.2) Start assessment Part IV (see 8.2) Week 0: Intervention-Phase Implementation of food supplement Complete assessment Part III (see 8.2) Third check of inclusion/exclusion criteria Week 3: Evaluation-Phase Complete assessment Part II, III and IV Fourth check of inclusion/exclusion criteria Compliance control 5.2 Methods of minimising bias (ICH/E6 6.4.3; AGEK 4.3; SPIRIT #16, 17) ICH: A description of the measures taken to minimize/avoid bias, including: Randomization, Blinding. Homogenous sample selection. 5.2.1 Randomisation Not applicable 5.2.2 Blinding procedures Not applicable 5.2.3 Other methods of minimising bias The investigators are going to do a semi-quantitative screening to determine a participant's nutritional habits. Questions about their nutritional habits asked in the screening (via questionnaire); 1. Does the participant have a particular or alternative lifestyle (e.g. vegan, vegetarian, only eating raw fruits and vegetables, etc.)? \- if yes → excluded 2. Does the participant control your nutrition in any form (food diary, app, counting calories, etc.)? \- if yes → excluded 3. Does the participant consciously eat food to strengthen your immune system or do you take additional supplements to influence your intestinal bacteria (e.g. pro- and/or prebiotic food like Actimel, Activia, etc.)? \- if daily or weekly → excluded 4. Does the participant exercise regularly? If yes, how often? - if 3h/week or more → excluded 5. On how many days per week does the participant eat meat or meat products? \- if less then twice and more than five times peer week → excluded 6. On how many days per week does the participant eat fish? \- if less or more than twice per week / 5 times per month → excluded 7. On how many days per week does the participant eat salad, vegetables or vegetable juice (not counting potatoes)? \- if less than 5 days per week → excluded 8. On how many days per week does the participant eat fruits or drink fruit juices approximately? \- if less than 5 days per week → excluded 9. On how many days per week does the participant drink or eat milk or milk products approximately? - if less than 4 days per week → excluded