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RESIPI for Reducing Perioperative Major Adverse Cardiac Events | Clinical Trials | Clareo Health

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RESIPI for Reducing Perioperative Major Adverse Cardiac Events

RESIPI for Reducing Perioperative Major Adverse Cardiac Events: A Phase II Prospective Randomized Controlled Trial

NCT03208023•Vanderbilt University Medical Center

Summary

This study aims to evaluate the effect of a novel hemodynamic management and monitoring strategy for reducing cardiac bio marker elevations and major adverse cardiac events.

Detailed Description

Modest elevations in cardiac biomarkers in the immediate postoperative period are associated with significantly increased risk of morbidity and mortality. The RESIPI model of hemodynamic monitoring and management in the perioperative period takes into account the dynamic interplay of vascular resistance, inotropy, and fluid management. This study aims to evaluate the effect of a novel hemodynamic management and monitoring strategy for reducing cardiac bio marker elevations and major adverse cardiac events.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Revised Cardiac Risk Index greater than or equal to 1, history of diastolic dysfunction, or age greater than 55 years.
•Surgery type: Major Abdominal Oncologic Surgery
•Planned surgery length greater than or equal to 90 minutes with planned in-patient stay of at least 2 days

Exclusion Criteria

•Patients who are unstable by current American Heart Association/American College of Cardiology Clinical Practice Guidelines
•Patients with Chronic Kidney Disease Stage IV or V
•Urgent/emergent surgical interventions (e.g. Level 1 or 2 by VUMC VOR definitions)
•No signs of ischemia, congestive heart failure, or volume overload: Creatinine Clearance greater than 30

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Key Dates

Start Date

October 9, 2017

Primary Completion Date

November 1, 2018

Completion Date

December 3, 2018

Last Updated

November 17, 2022

Enrollment

155

ACTUAL participants

Conditions

InotropyFluid ManagementCardiac EventPerioperative Cardiac RiskVascular ResistanceHemodynamic MonitoringHemodynamic ManagementFluid Responsiveness

Interventions

RESIPI Management Strategy

PROCEDURE

No intervention

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 17, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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RESIPI for Reducing Perioperative Major Adverse Cardiac Events

Inclusion Criteria

Exclusion Criteria

Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery

Prediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonography and Echocardiography

Pericardiotomy in Cardiac Surgery

Maternal and Offspring Outcomes in Pregnant Women With Pre-existing ASCVD

Advancing Health Information Exchange (HIE) During Inter-hospital Transfer (IHT) to Improve Patient Outcomes

Study Of Ultrasound Windows For Measuring Inferior Vena Cava Changes Before Cardiac Surgery