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Effect of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy | Clinical Trials | Clareo Health

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Effect of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy

Effect of Intrathecal Transplant of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy

NCT03107975•The Second Affiliated Hospital of Fujian Medical University

Summary

This study aimed to evaluate the therapeutic potential of human amniotic epithelial cell (hAEC) transplant in the management of children with spastic cerebral palsy.

Detailed Description

Cerebral palsy is one of the most common congenital (existing at or before birth) disorders of childhood.Spastic cerebral palsy causes stiffness and movement difficulties.There is no cure for the disease now. This study aimed to evaluate the therapeutic potential of human amniotic epithelial cell (hAEC) transplant in the management of children with spastic cerebral palsy. hAEC will be intrathecal transplanted. Functional status is determined by Gross Motor Function Measure-66 and Fine Motor Function Measure. Spasticity is evaluated by using modified Ashworth scale(MAS).

Eligibility

Age

1 - 5 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Signed informed consent document;
•Gross Motor Function Classification System (GMFCS) levels III-V;
•Parents accepted voluntarily cell therapy for their children and followed-up.

Exclusion Criteria

•Have a history of severe allergic;
•Serological tests such as AIDS, hepatitis B, syphilis, etc;
•Hereditary metabolic diseases of nervous system;
•Tumor or Hematological diseases.

Locations (1)

The Second Affiliated Hospital of Fujian Medical University

Quanzhou, Fujian, China

Key Dates

Start Date

April 1, 2017

Primary Completion Date

December 31, 2017

Completion Date

December 31, 2018

Last Updated

April 26, 2017

Enrollment

ESTIMATED participants

Conditions

Spastic Cerebral Palsy

Interventions

human amniotic epithelial cells

BIOLOGICAL

Talocrural Mobilization With Movement in Spastic Cerebral Palsy

NCT06598657

Spastic Cerebral Palsy (sCP)

View study

RECRUITINGNA

Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy

NCT05571033

Cerebral PalsySpastic Cerebral Palsy

View study

COMPLETEDNA

Short Term Follow-up of a Botulinum Toxin Intervention in Children With Spastic Cerebral Palsy

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 26, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy

Inclusion Criteria

Exclusion Criteria

Talocrural Mobilization With Movement in Spastic Cerebral Palsy

Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy

Short Term Follow-up of a Botulinum Toxin Intervention in Children With Spastic Cerebral Palsy

Impact of AFOs on the GMF of Children With CP or ABI

The Effects of Oral Facial Facilitation and Oral Motor Therapy in Dysphagia

Effect of AO Training on Gross Motor Function in Children with Spastic Cerebral Palsy