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Feeding Malnourished Children Different Types of Fatty Acids to Promote Neurocognitive Development | Clinical Trials | Clareo Health

COMPLETEDNA

Feeding Malnourished Children Different Types of Fatty Acids to Promote Neurocognitive Development

Improved Polyunsaturated Ready-to-use Therapeutic Food for Improved Neurocognitive Outcomes in Severe Acute Malnutrition

NCT03094247•Washington University School of Medicine

View on ClinicalTrials.gov

Summary

An appropriate balance of omega-6 and omega-3 fatty acids is important for support of neurocognitive development in healthy infants and toddlers. In young children recovering from severe acute malnutrition (SAM), excess omega-6 intake depletes omega-3 fatty acid status. This research will evaluate how novel ready-to-use therapeutic foods (RUTF) with balanced fatty acids improve the metabolic and neurocognitive effects in young children in Malawi recovering from SAM, yielding new knowledge that also has implications for development of well-nourished children.

Eligibility

Age

0 - 4 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•6-59 months
•An acceptable appetite defined by the ability to consume 30 grams RUTF within 20 minutes
•Mid Upper Arm Circumference \<11.5 cm, weight-for-height z-score \< -3, or bilateral pitting edema on the dorsum of the feet

Exclusion Criteria

•Participation in any other ongoing study or supplementary feeding program
•Children with a chronic medical condition, including cerebral palsy, static encephalopathy, congenital heart disease, gastrointestinal disease, or peanut allergy

Locations (1)

University of Malawi College of Medicine

Blantyre, Malawi

Key Dates

Start Date

October 2, 2017

Primary Completion Date

March 23, 2021

Completion Date

March 23, 2021

Last Updated

July 19, 2022

Enrollment

2,897

ACTUAL participants

Conditions

Severe Acute Malnutrition

Interventions

Amoxicillin

DRUG

HO-RUTF

DIETARY_SUPPLEMENT

D-HO-RUTF

DIETARY_SUPPLEMENT

S-RUTF

DIETARY_SUPPLEMENT

Choline to Improve Malnutrition and Enhance Cognition

NCT06154174

Severe Acute MalnutritionCognitive Impairment+2 more

View study

RECRUITINGNA

Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition

NCT06869850

Severe Acute MalnutritionCognitive Impairment+2 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 19, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Feeding Malnourished Children Different Types of Fatty Acids to Promote Neurocognitive Development

Inclusion Criteria

Exclusion Criteria

Choline to Improve Malnutrition and Enhance Cognition

Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition

Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute Malnutrition

Family Mid-Upper Arm Circumference (MUAC) Follow-up After Recovery From Acute Malnutrition (MODAM-fMUAC)

Development of a Diagnostic Prediction Score for Tuberculosis in Hospitalized Children With Severe Acute Malnutrition (TB-Speed SAM)

Trial of Rice-Based F-75 in Severe Malnutrition & Persistent Diarrhea in Children (SAM-RICE Study)