Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy

Inclusion Criteria

• •Age 18-89
• •Acute renal failure or end-stage renal disease necessitating CRRT
• •Admitted to the MICU service
• •If on vasopressor/inotropic agent, norepinephrine as only intravenous pressor
• •If on vasopressor/inotropic agent, at stable pressor dose for at least four hours
• •If on IV fluids, stable dose of crystalloids \<= 100cc/hour and is not receiving colloids for 4 hours or more prior to initiation of CRRT
• •Mean arterial pressure (MAP) \>= 65
• •Arterial catheter present for continuous blood pressure monitoring
• •CRRT duration of 48 hours or less using NxStage System One dialysis system
• •successfully tolerated CRRT for at least 4 hours without clotting or hemodynamic instability
• •no other procedures, blood products transfusion, or additional medication administration are anticipated during the study period