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Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy | Clinical Trials | Clareo Health

TERMINATEDNA

Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy

NCT03078504•St. Louis University

Summary

Purpose of this study is to evaluate the short-term hemodynamic effects of changes in blood flow rates in critically ill patients receiving continuous renal replacement therapy.

Eligibility

Age

18 - 89 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age 18-89
•Acute renal failure or end-stage renal disease necessitating CRRT
•Admitted to the MICU service
•If on vasopressor/inotropic agent, norepinephrine as only intravenous pressor
•If on vasopressor/inotropic agent, at stable pressor dose for at least four hours
•If on IV fluids, stable dose of crystalloids \<= 100cc/hour and is not receiving colloids for 4 hours or more prior to initiation of CRRT
•Mean arterial pressure (MAP) \>= 65
•Arterial catheter present for continuous blood pressure monitoring
•CRRT duration of 48 hours or less using NxStage System One dialysis system
•successfully tolerated CRRT for at least 4 hours without clotting or hemodynamic instability
+1 more criteria

Exclusion Criteria

•listed for organ transplant
•atrial fibrillation, other irregular heart rhythm, unstable arrhythmia
•need for more than one intravenous vasopressor agent
•intravenous vasopressor/inotropic agent other than norepinephrine (ie dobutamine, dopamine, vasopressin, epinephrine)
•therapeutic anticoagulation being administered
•known acute myocardial infarction as defined by elevated troponin along with a documented clinical diagnosis during current hospitalization
•known acute stroke, intracerebral hemorrhage, intracranial mass effect, or elevated intracranial pressure within the last 30 days.
•dialysis catheter malfunction and unable to maintain target blood flow rate
•fluid removal (ultrafiltration) rate \> 100mL/hour

Locations (1)

Saint Louis University

St Louis, Missouri, United States

Key Dates

Start Date

February 17, 2017

Primary Completion Date

June 6, 2018

Completion Date

June 30, 2018

Last Updated

March 30, 2020

Enrollment

ACTUAL participants

Conditions

Acute Kidney InjuryEnd-stage Renal Disease

Interventions

continuous renal replacement therapy using System One (TM) setup (Nxstage)

DEVICE

UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events

NCT05806645

Acute Kidney Injury

View study

RECRUITINGNA

Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System

NCT04634916

Kidney Disease, End-StageEnd-stage Renal Disease+1 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 30, 2020Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy

Inclusion Criteria

Exclusion Criteria

UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events

Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System

Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat

WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients

Outpatient Recovery From Acute Kidney Injury Requiring Dialysis - 2

Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients