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PERIODONTITIS AND VASCULAR DYSFUNCTION | Clinical Trials | Clareo Health

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PERIODONTITIS AND VASCULAR DYSFUNCTION

INTENSIVE TREATMENT FOR PERIODONTAL DISEASE: A MODEL OF AND THERAPY OF INFLAMMATORY VASCULAR DYSFUNCTION

NCT03072342•University College, London

Summary

The investigators wish to assess whether intensive periodontal therapy will reduce the burden of chronic periodontal disease and will cause regression or prevent progression of atherosclerosis assessed by a surrogate end-point (carotid intima-media thickness) at 24 months compared to control periodontal therapy.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Participants must be ≥ 18 years-old.
•2. Participants must have moderate to severe periodontitis (at least 30 periodontal pockets \> 4mm with Bleeding on Probing) and radiographic signs of bone loss.
•3. Participants must have voluntarily signed the informed consent.

Exclusion Criteria

•1. Female participant is pregnant or lactating or of childbearing and not using acceptable methods of birth control.
•2. Participant is on chronic treatment (i.e., two weeks or more) with specific medications known to affect periodontal status (phenytoin or cyclosporine) within one month of baseline visit.
•3. Participant knowingly has HIV or Hepatitis.
•4. Participant has limited mental capacity or language skills such that simple instructions cannot be followed or information regarding adverse events cannot be provided.
•5. Participant on chronic antibiotic therapy or who require antibiotic coverage for periodontal procedures.
•6. Participant had a course of periodontal therapy in the preceding 6 month

Locations (1)

UCL-Eastman Dental Institute

London, United Kingdom

Key Dates

Start Date

April 16, 2013

Primary Completion Date

March 30, 2020

Completion Date

March 30, 2020

Last Updated

January 25, 2021

Enrollment

190

ACTUAL participants

Conditions

PeriodontitisIntimal Medial Thickness of Internal Carotid Artery

Interventions

Intensive Periodontal Treatment

PROCEDURE

Control Periodontal Treatment

PROCEDURE

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RECRUITING

Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 25, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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PERIODONTITIS AND VASCULAR DYSFUNCTION

Inclusion Criteria

Exclusion Criteria

Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis

Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France

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Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management

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Assessment of Dental Pathologies Using Digital Tools