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Role of Circulating Innate Lymphoid Cells in Allergic Disorders | Clinical Trials | Clareo Health

TERMINATED

Role of Circulating Innate Lymphoid Cells in Allergic Disorders

NCT03069495•University of Nebraska

Summary

This study evaluates blood type 2 innate lymphoid cells in participants with mild to moderate asthma and participants with chronic urticaria as compared to healthy adult participants.

Detailed Description

The first objective of this study is to determine whether blood ILC2s differ in female vs. male allergic asthmatics. This is because females become more susceptible to asthma after puberty and experience more severe disease as adults. The second objective of this study is to determine whether ILC2 cells in chronic urticaria differ from healthy controls. There will be one shared healthy control adult subject group for comparison for objective 1 and 2. In this study, there will be a blood draw once on 3 different adult populations aged 19-50 years: 1) Participants with mild-to moderate allergic asthma; 2) Participants with chronic urticaria, and 3) Healthy control adult participants. Demographics and allergy indicators will be collected from the medical chart. The investigators will acquire whole blood for serum and acquisition of specific lymphocyte populations. There will be no intervention or research follow up.

Eligibility

Age

19 - 50 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Adult subjects between age 19-50 years.
•2. Non-smokers, defined as \< 100 cigarettes in lifetime.

Exclusion Criteria

•1. Female donors will be excluded if they are menopausal or have undergone total abdominal hysterectomy and/or bilateral salpingoophorectomy
•2. For female donors, blood draw cannot occur during menstrual period time. Subjects will be excluded if they have menstrual period at timing of blood draw.
•3. Current and past smokers.
•4. Subjects with asthma and any other lung disease including chronic obstructive pulmonary disease, interstitial lung disease, pulmonary hypertension, sarcoidosis, cystic fibrosis.
•5. Pregnant or lactating subjects
•6. Subjects with hypercalcemia (\> 10.3 mg/dL), renal insufficiency (glomerular filtration rate \[GFR\] \< 50 mL/min/1.73m2), or malignancy.
•7. Subjects with any symptoms of respiratory infection in the past 4 weeks.
•8. Subjects unable to hold leukotriene modifiers or antihistamines for at least 24 hours prior to blood draw.
•9. Subjects on any immunomodulators, including omalizumab, or systemic corticosteroid in the past 4 weeks.

Locations (1)

University of Nebraska Medical Center

Omaha, Nebraska, United States

Key Dates

Start Date

August 21, 2017

Primary Completion Date

February 24, 2020

Completion Date

February 24, 2020

Last Updated

August 28, 2023

Enrollment

ACTUAL participants

Conditions

AllergyAsthmaUrticaria

NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)

NCT02327897

Asthma

View study

RECRUITINGNA

Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)

NCT07486401

Asthma ExacerbationsBiomarkers / Blood+1 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 28, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Role of Circulating Innate Lymphoid Cells in Allergic Disorders

Inclusion Criteria

Exclusion Criteria

NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)

Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)

A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

Relationship of Airway Microbiota, Endotype and Phenotype in Adult Asthma

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

To Assess the Management of Patients on Global Initiative of Asthma (GINA) Step 4 and 5 Treatment in Hong Kong