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The Effect of Motilin on the Frequency and Amount of Food Intake | Clinical Trials | Clareo Health

ENROLLING_BY_INVITATIONPHASE4

The Effect of Motilin on the Frequency and Amount of Food Intake

Influence of Erythromycin on ad Libitum Food Intake and the Evaluation of Motilin in Food Timing in Healthy Volunteers and Patients

NCT03024879•Universitaire Ziekenhuizen KU Leuven

View on ClinicalTrials.gov

Summary

In this study, the investigators aimed at evaluating the role of motilin in the regulation of food intake. Motilin, a gastrointestinal hormone, is a hunger signal in healthy volunteers and is significantly increased in obese patients. Its role in food intake regulation might contribute to the pathogenesis of obesity.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•BMI \< 30 kg/m² for lean volunteers
•BMI \> 30 kg/m² for obese volunteers
•Subject is capable and willing to give informed consent
•Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception

Exclusion Criteria

•Female volunteer is pregnant or breastfeeding
•GI diseases, major abdominal surgery
•Major psychiatric illnesses
•Volunteers that use drugs affecting the GI tract or the central nervous system
•Volunteers suffering from endocrine diseases such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
•Volunteers that have undergone surgical procedure for weight loss

Key Dates

Start Date

March 1, 2014

Primary Completion Date

March 1, 2025

Completion Date

March 1, 2025

Last Updated

July 10, 2024

Enrollment

ESTIMATED participants

Conditions

HealthyObesity

Interventions

Erythromycin

DRUG

Saline

DRUG

A New Portable Device for Non-invasive Ventilatory Support

NCT06716502

HealthyRespiratory Disease

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RECRUITINGPHASE1

Research Into the Safety of a New Agent (VT-5006) in People With and Without Parkinson's Disease

NCT07310264

Healthy Volunteers (HV)Parkinson's Disease (PD)

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 10, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Effect of Motilin on the Frequency and Amount of Food Intake

Inclusion Criteria

Exclusion Criteria

A New Portable Device for Non-invasive Ventilatory Support

Research Into the Safety of a New Agent (VT-5006) in People With and Without Parkinson's Disease

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Collection of Data and Samples From Healthy Donors for Use in Translational Research

Multi-Acupoint Laser Therapy for Body Shape and Composition in Obese Menopausal Women

Fecal Microbiota Transplantation for Patients With Autism Spectrum Disorder.