A Study in Adults and Adolescents With Angelman Syndrome (STARS)

Exclusion Criteria

• •1. Unable to perform the study related safety and exploratory efficacy assessments, such as motor function
• •2. Poorly controlled seizure activity
• •3. Concomitant cardiovascular, respiratory, liver, renal, or hematologic diseases of a degree that would limit participation in the study
• •4. Pregnancy or women of child-bearing potential who are not using and acceptable method of contraception
• •5. Concomitant use of minocycline, levodopa, zolpidem, zaleplon, eszopiclone, ramelteon, and cannabinoid derivatives, or any other use of any investigational agent, device, and/or investigational procedure 4 weeks prior to Baseline and during the study
• •6. Allergy to OV101 or any excipients
• •7. At increased risk of harming self and/or others based on investigator assessment
• •8. Any condition or reason that in the opinion of the investigator makes the subject unsuitable for enrollment
• •9. Inability of subject or caregiver to comply with study requirements