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The Effect of Rapid Transcranial Magnetic Stimulation (rTMS) on Aggression in Forensic Patients

NCT02990442•St. Joseph's Healthcare Hamilton

Summary

Forensic patients will undergo 30 rTMS treatments, once per day each business day using a 1Hz frequency at the right dorso-lateral pre frontal cortex, located using modified BEAM F3. Patients will be assessed before and after the study with a battery of assessments and using 2 computer tasks: a ball passing task, and the Point Subtraction Aggression Paradigm (PSAP). The investigators will also monitor and record aggressive incidents that take place on the unit.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. are voluntary and competent to consent to treatment
•2. are a current Forensics inpatient at St. Joseph's West 5th Campus
•3. demonstrate aggressive behavior as confirmed by a psychologist or psychiatrist including verbal and physical aggression
•4. are between the ages of 18 and 65
•5. have had no changes in dose or initiation of any psychotropic medication in the 4 weeks prior to motor threshold
•6. are willing and able to adhere to the treatment schedule
•7. pass the TMS adult Safety-Screening (TASS) Questionnaire

Exclusion Criteria

•1. Withdraw consent to participate in the study
•2. fail the TASS Safety Screening Questionnaire
•3. have a concomitant major unstable medical illness, cardiac pacemaker or implanted medication pump, or a significant history of seizures
•4. have active suicidal intent
•5. are pregnant as confirmed by pregnancy test completed as part of pre-study screening
•6. have any significant neurological disorder or insult including, but not limited to: any condition likely to be associated with increased intracranial pressure, space occupying brain lesion, any significant history of seizure except those therapeutically induced by electroconvulsive therapy (ECT), cerebral aneurysm, Parkinson's disease, Huntington's chorea, multiple sclerosis
•7. have an intracranial implant (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head, excluding the mouth, that cannot be safely removed
•8. currently (or in the last 4 weeks) take more than lorazepam 2 mg daily (or equivalent) due to seizure risk or any dose of an anticonvulsant due to the potential to limit rTMS efficacy
•9. non-correctable clinically significant sensory impairment (i.e., cannot hear well enough to cooperate with interview).

Locations (1)

St. Joseph's Healthcare Hamilton

Hamilton, Ontario, Canada

Key Dates

Start Date

November 1, 2017

Primary Completion Date

March 1, 2020

Completion Date

March 1, 2020

Last Updated

April 22, 2019

Enrollment

ESTIMATED participants

Conditions

Aggression

Interventions

rTMS

DEVICE

Contacts

Sheila Verhage-Brown, MD

CONTACT

905-522-1155 sverhage@stjoes.ca

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 22, 2019Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Effect of Rapid Transcranial Magnetic Stimulation (rTMS) on Aggression in Forensic Patients

Inclusion Criteria

Exclusion Criteria

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