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Cirrhosis results in decreased synthesis of both procoagulants and anticoagulants resulting in "rebalanced homeostasis". However, conventional blood tests (platelets/ INR levels) that are performed prior to invasive procedures do not accurately reflect the coagulation changes that occur in cirrhotics, resulting in unnecessary transfusion of blood products. Thromboelastography (TEG) is a global hemostasis assessment tool that is being used in surgery (including liver transplant) to help guide blood product transfusion in the operating room. The investigators would like to compare the use of TEG vs. INR/platelets to help guide blood product transfusion in cirrhotic patients undergoing inpatient endoscopy. The investigators will evaluate to see if there is a decrease in prophylactic blood transfusions prior to endoscopy when using TEG.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Start Date
January 1, 2017
Primary Completion Date
January 19, 2021
Completion Date
January 19, 2021
Last Updated
January 22, 2021
1
ACTUAL participants
Blood transfusion
BIOLOGICAL
Lead Sponsor
Johns Hopkins University
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