Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Beijing Chao Yang Hospital
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
AECOPD confirmed by the 2019 criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD)
Arterial pH \<7.35 and PaCO2 \>45 mmHg at screening entry
PaCO2 \>45 mmHg after a 6-hour trial of low-intensity NPPV
You may not be if
Age \<18 years
Excessive respiratory secretions with weak cough
Upper airway obstruction
Recent oral, facial, or cranial trauma or surgery
Recent gastric or esophageal surgery
Presence of restrictive ventilatory dysfunction (eg, consolidation or removal of at least one pulmonary lobe, massive pleural effusion, chest wall deformity, continuous strapping with thoracic or abdominal bandage, or severe abdominal distension)
Active upper gastrointestinal bleeding
Cardiac or respiratory arrest
Arterial oxygen tension/fraction of inspired oxygen (PaO2/FiO2) \<100 mmHg
Pneumothorax
Obvious emphysematous bullae confirmed by chest CT scan
Ventricular arrhythmia or myocardial ischemia
Severe hemodynamic instability (mean arterial pressure \<65 mmHg)
Severe metabolic acidosis (pH \<7.20 and bicarbonate \<22 mmol/L)
Refusal to receive NPPV or give informed consent
Prior endotracheal intubation or tracheostomy during the current hospitalization
