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Effects of Sublingual and Transdermal Administration of Nitroglycerin for Coronary CT Angiography on Image Quality | Clinical Trials | Clareo Health

COMPLETEDPHASE4

Effects of Sublingual and Transdermal Administration of Nitroglycerin for Coronary CT Angiography on Image Quality

NCT02961946•Massachusetts General Hospital

View on ClinicalTrials.gov

Summary

To evaluate image quality of coronary CT angiography (cCTA) after sublingual and transdermal administration of Nitroglycerin. Aim of this prospective research study is to investigate equivalence on image quality after sublingual or transdermal Nitroglycerin administration (H0). Furthermore, the feasibility of transdermal Nitroglycerin administration will be evaluated.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Scheduled cCTA with contrast.
•2. Able to comprehend and sign the consent form.

Exclusion Criteria

•1. Known hypersensitivity to glyceryl trinitrate, and related organic nitrates.
•2. Acute circulatory failure associated with marked hypotension (shock).
•3. Conditions associated with elevated intracranial pressure, cerebral haemorrhage and head trauma.
•4. Closed-angle glaucoma.
•5. Phosphodiesterase type 5 (PDE5) inhibitors such as sildenafil (Viagra®), tadalafil (Cialis), or vardenafil (Levitra) within the last 24 hours
•6. Unstable clinical conditions (i.e. hemodynamic instability, arrhythmias)
•7. Critical aortic stenosis
•8. Systolic blood pressure \< 90 mmHg
•9. Pregnant or lactating female; premenopausal women with a positive urine pregnancy test.
•10. Age under 18
+1 more criteria

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Key Dates

Start Date

March 15, 2017

Primary Completion Date

October 31, 2017

Completion Date

August 2, 2018

Last Updated

September 17, 2019

Enrollment

198

ACTUAL participants

Conditions

Coronary Artery Disease

Interventions

Nitroglycerin

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 17, 2019Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Effects of Sublingual and Transdermal Administration of Nitroglycerin for Coronary CT Angiography on Image Quality

Inclusion Criteria

Exclusion Criteria

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