Triggering of Follicular Maturation

Triggering of Follicular Maturation Using Human Chorionic Gonadotrophin With Gonadotrophin Releasing Hormone Agonist Versus Human Chorionic Gonadotrophin Alone in Antagonist Protocol in Assisted Reproductive Technology : a Randomized Controlled Trial

NCT02916173•Assiut University

View on ClinicalTrials.gov

Summary

The follicular phase of the menstrual cycle involves the hourly release of gonadotropin-releasing hormone, which binds to receptors on the gonadotropes. This results in the secretion of follicle stimulating hormone and luteinizing hormone in hourly pulses that regulate follicular growth. At midcycle, rapidly rising estradiol from the dominant follicle and a small rise in progesterone lead to a gonadotrophic surge. An increase in the amplitude of Luteinizing hormone and Follicle stimulating hormone pulses initiates oocyte maturity and triggers ovulation approximately

Eligibility

Age

20 - 40 years

Sex

FEMALE

Healthy Volunteers

Inclusion Criteria

•1. Infertile couples wishing to do intracytoplasmic injection trial .
•2. first intracytoplasmic injection trial
•3. Body mass index:18-30.
•5-Antral follicular count: more than 5 follicles in one ovary 6-normal, mild or moderate male factor infertility. 7- Antimullerian hormone \>1 ng/ml

Exclusion Criteria

•1. Azoospermic male.
•2. Body mass index more than 29.
•3. Patients with endometriosis .
•4. Antimullerian hormone \< 1 ng/ml

Locations (1)

Ahmed Abbas

Assiut, Cairo Governorate, Egypt

Key Dates

Start Date

November 1, 2016

Primary Completion Date

October 1, 2018

Completion Date

February 1, 2019

Last Updated

March 20, 2019

Enrollment

160

ACTUAL participants

Conditions

Increase Pregnancy Rate

Interventions

Recombinant Human Chorionic Gonadotrophin

DRUG

human chorionic gonadotrophin + gonadotrophin releasing hormone agonist

DRUG