Berberine Prevent Contrast-induced Nephropathy in Patients With Diabetes

Exclusion Criteria

• •Hypersensitivity to iodine-containing compounds and berberine
• •Ketoacidosis
• •Lactic acidosis
• •CKD stages 1, 5 (eGFR≥90ml/min per 1.73m2 or eGFR\<15ml/min per 1.73m2)
• •STEMI
• •NYHA class IV or hemodynamic instability
• •Administration of any iodinated contrast medium within 14 days before randomization
• •LDL-C\<1.82mmol/L（70mg/dL）
• •Hepatic dysfunction (ALT 3 times greater than upper normal limit)
• •Thyreoid insufficiency
• •Renal artery Stenosis(unilateral \>70％ or bilateral stenosis\>50％)