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PPARγ Agonist Treatment for Cocaine Dependence | Clinical Trials | Clareo Health

COMPLETEDPHASE1/PHASE2

PPARγ Agonist Treatment for Cocaine Dependence

NCT02774343•The University of Texas Health Science Center, Houston

Summary

The purpose of this research study is to determine whether a medication called pioglitazone (trade name Actos) can reduce behavioral problems associated with cocaine use, improve brain structural changes associated with cocaine use and reduce cocaine craving and drug use in cocaine dependent patients.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•DSM-IV criteria for cocaine dependence
•At least one cocaine positive urine during screening
•Female subjects: a negative pregnancy test
•Be in acceptable health on the basis of interview, medical history and physical exam
•Be able to understand the consent form and provide written informed consent
•Be able to provide the names of at least 2 persons who can generally locate their whereabouts.

Exclusion Criteria

•Current Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV diagnosis of any psychoactive substance dependence other than cocaine marijuana, alcohol, or nicotine
•Any serious medical or psychiatric illness and/or clinically significant abnormal laboratory value, which in the judgment of the Principal Investigator or his/her designee would make study participation unsafe, or would make treatment compliance difficult or put the study staff at undue risk
•Significant current suicidal or homicidal ideation
•Medical conditions contraindicating pioglitazone pharmacotherapy (e.g., congestive heart failure as determined by Framingham criteria, clinically significant edema, clinically significant liver disease, hypoglycemia, diabetes, history of bladder cancer)
•Taking medications known to have significant drug interactions with the study medication (CYP2C8 inhibitors or inducers, antihyperglycemic medications)
•Currently being treated for substance misuse with medication
•Conditions of probation or parole requiring reports of drug use to officers of the court
•Impending incarceration
•Pregnant or planning to become pregnant during the course of the trial or nursing for female patients
•Inability to read, write, or speak English (many of the research instruments in this study only exist in English)
+4 more criteria

Locations (1)

The University of Texas Health Science Center at Houston

Houston, Texas, United States

Key Dates

Start Date

August 1, 2012

Primary Completion Date

June 1, 2015

Completion Date

June 1, 2015

Last Updated

April 26, 2018

Enrollment

ACTUAL participants

Conditions

Cocaine Use DisorderAlcohol Use Disorder

Interventions

Pioglitazone

DRUG

Placebo

DRUG

Therapy

BEHAVIORAL

Contingency Management

BEHAVIORAL

Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment

NCT05855668

Alcohol Use DisorderCannabis Use Disorder

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RECRUITINGNA

Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder

NCT07071779

Alcohol Use Disorder (AUD)Cocaine Use Disorder (CUD)+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 26, 2018Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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PPARγ Agonist Treatment for Cocaine Dependence

Inclusion Criteria

Exclusion Criteria

Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment

Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder

Virtual Reality (VR) NATURE - Alcohol Use Disorder (AUD)

Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder

Anxiety During Abstinence in AUD

Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)