PPARγ Agonist Treatment for Cocaine Dependence

Exclusion Criteria

• •Current Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV diagnosis of any psychoactive substance dependence other than cocaine marijuana, alcohol, or nicotine
• •Any serious medical or psychiatric illness and/or clinically significant abnormal laboratory value, which in the judgment of the Principal Investigator or his/her designee would make study participation unsafe, or would make treatment compliance difficult or put the study staff at undue risk
• •Significant current suicidal or homicidal ideation
• •Medical conditions contraindicating pioglitazone pharmacotherapy (e.g., congestive heart failure as determined by Framingham criteria, clinically significant edema, clinically significant liver disease, hypoglycemia, diabetes, history of bladder cancer)
• •Taking medications known to have significant drug interactions with the study medication (CYP2C8 inhibitors or inducers, antihyperglycemic medications)
• •Currently being treated for substance misuse with medication
• •Conditions of probation or parole requiring reports of drug use to officers of the court
• •Impending incarceration
• •Pregnant or planning to become pregnant during the course of the trial or nursing for female patients
• •Inability to read, write, or speak English (many of the research instruments in this study only exist in English)
• •Having plans to leave the immediate geographical area within 3 months
• •Unwillingness to sign a written informed consent form
• •Unwillingness to use a barrier method of birth control during the study for female patients
• •History of pacemaker or metal implants or welding or metal work without protective eyewear (for risk of MRI scans).