Treatment of PCNSL With R-IDARAM and Intrathecal Immunochemotherapy

Exclusion Criteria

• •Involved sites other than the brain, meninges, CSF, or the eyes.
• •Age less than 18 years or greater than 75 years.
• •Inadequate bone marrow capacity (defined as neutrophils\<1.5 ×10\^9/L, platelets \<100 ×10\^9/L, and hemoglobin level\< 8 g/dL).
• •Known cause of immunosuppression (ie, HIV type I infection).
• •Any previous malignancy.
• •Creatinine clearance below 60 mL/min.
• •Heart insufficiency (NYHA IIIB or IV).
• •Uncontrolled infection.
• •Noncompensated active pulmonary or liver disease.
• •Previously treated for PCNSL, except by corticosteroids.