Autologous Prefabrication of Body Surface Tissues/ Organs(e.g. Joint)

Exclusion Criteria

• •evidence of infection, ischemia, ulcer or other pathological changes within the prefabricated area which defined as not suitable for tissues regeneration
• •history of delayed healing, radiational therapy;
• •significant renal, cardiovascular, hepatic and psychiatric diseases;
• •significant medical diseases or infection (including but not limited to the carrier of hepatitis B virus or HIV);
• •BMI \>30;
• •history of any hematological disease, including leukopenia, thrombocytopenia, or thrombocytosis;
• •Evidence of malignant diseases
• •unwillingness to participate.