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Prospective Study for Transplant Optimization Using Functional Imaging (TROFI) | Clinical Trials | Clareo Health

TERMINATEDPHASE2

Prospective Study for Transplant Optimization Using Functional Imaging (TROFI)

NCT02488304•FLUIDDA nv

Summary

The objective of this study is to detect BOS in an early stage by using the outcome parameters generated by Functional Respiratory Imaging (FRI). Robust and automated segmentation algorithms will be developed for these parameters, focusing on quantitative computed tomography (CT) image analyses to provide the physician a more sensitive diagnostics tool. The evolution of rejection over time will be monitored using non-rigid image registration methods.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Male or female patient ≥ 18 years old
•Written informed consent obtained
•Patients who are planned to receive a lung transplant in the near future
•Female patient of childbearing potential who confirm that a contraception method was used at least 14 days before screening visit and will continue to use a contraception method during the study
•The patient must be able to perform the lung monitoring at home

Exclusion Criteria

•Pregnant or lactating female
•Known history of or active airways or anastomotic complications requiring intervention such as stenting or dilation

Locations (1)

Antwerp University Hospital

Edegem, Antwerp, Belgium

Key Dates

Start Date

July 1, 2015

Primary Completion Date

December 15, 2017

Completion Date

December 15, 2017

Last Updated

March 21, 2018

Enrollment

ACTUAL participants

Conditions

Bronchiolitis ObliteransLung Transplant Rejection

Interventions

HRCT scans

RADIATION

Developing Hyperpolarized Gas MRI Signatures to Detect and Manage Acute Cellular Rejection

NCT07046910

Lung Transplant Rejection

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RECRUITING

Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation

NCT02812290

Lung Transplant Rejection

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RECRUITINGPHASE2

LAM-001 in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome.

NCT06018766

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 21, 2018Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Prospective Study for Transplant Optimization Using Functional Imaging (TROFI)

Inclusion Criteria

Exclusion Criteria

Developing Hyperpolarized Gas MRI Signatures to Detect and Manage Acute Cellular Rejection

Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation

LAM-001 in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome.

TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Response to Extracorporeal Photo-aphereSiS

Extracorporeal Photopheresis for Medicare Recipients of Lung Allografts

Prospective Evaluations of Infectious Complication in Lung Transplant Recipients