An Open Study to Assess the Robustness of the CRC749 Inhaler

Exclusion Criteria

• •1. Other chronic or active respiratory disorder or symptoms of, or treatment for a COPD or asthma exacerbation during the 28 days preceding screening.
• •2. History of long QT syndrome or screening ECG with QTcF greater than 480 milliseconds.
• •3. Current evidence of, or history within the 6 months prior to screening of unstable ischemic heart disease, NYHA Class III/IV left ventricular failure, or myocardial infarction.
• •4. Subjects in whom Advair(R) Diskus(R) / Seretide(R) Accuhaler(R) are contra-indicated.