Hypofractionated Stereotactic Body Radiation Therapy for Patients With Prostate Cancer That Was Removed by Surgery

Inclusion Criteria

• •Adenocarcinoma of the prostate treated primarily with radical prostatectomy
• •* Any type of radical prostatectomy is permitted including retropubic, perineal, laparoscopic or robotically assisted; there is no time limit for the date of radical prostatectomy
• •One of the following pathologic classifications
• •* T3N0 disease with or without a positive surgical margin or
• •* T2N0 disease with or without a positive surgical margin
• •* Those with T2N0 disease and a negative margin must have a detectable prostate-specific antigen (PSA) following radical prostatectomy or
• •* Must have had an undetectable PSA after prostatectomy and has since had a rise in post-operative PSA to 0.2 ng/mL or greater
• •Zubrod performance status of 0 -1
• •No distant metastases, based on the following workup within 60 days prior to registration
• •* Magnetic resonance imaging (MRI) of the pelvis
• •* Bone scan or sodium fluoride positron emission tomography (PET), that if suspicious has MRI or plain X-rays to rule out bone metastasis
• •Patients can be on androgen deprivation therapy
• •Ability to understand and willingness to sign a study-specific informed consent prior to study entry