Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University Hospital, Tours
With
HOSPITAL, ORLEANS
Poitiers University Hospital
Centre Hospitalier de La Rochelle
HOSPITAL, SAINTES
HOSPITAL, FOCH
HOSPITAL, CAEN
Henri Mondor University Hospital
Hotel Dieu Hospital
HOSPITAL, CHARTRES
HOSPITAL, SAINT LOUIS
Tourcoing Hospital
Central Hospital, NIORT
Tenon Hospital, Paris
Central Hospital, Nancy, France
University Hospital, Rouen
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
HIV-1 infected patient
Initial TT ARV started above (or equal to) 150 / mm3 LT CD4, and 18 months prior to inclusion in the study
Ongoing antiretroviral therapy combining tenofovir + emtricitabine + a 3rd agent (IP / r, IP, NNRTI, II, Inhibitors) with at least one undetectable viral load (CV \<50 copies / mL) after introduction of the latter treatment.
Patient in virological success: CV \<50 copies / mL for at least 12 months, including visit to selection.
Absence of previous therapeutic failure: no viral load ≥ 200 copies / mL (after 6 months of treatment) (Except in the case of a justified therapeutic interruption: travel, stock-out ...) and of obtaining success Virologic after introduction of treatment, without concept of genotypic resistance known to the ARVs used.
Cellular DNA-HIV \<2.7 log copies / 106 PBMC
Zenith RNA-HIV \<150,000 copies / ml (excluding viral load values during primary infection if it is documented)
No genotypic resistance to currently used and known ARVs
Patient who has given written informed consent
Affiliate or beneficiary of a social security scheme
Patient followed on an outpatient basis, age ≥ 18 years.
You may not be if
Non-compliant patient
Subject is pregnant, or lactating, or of childbearing potential and without contraception
Active opportunistic infections
Major overweight (BMI ≥ 40)
Severe renal pathology (creatinine clearance \< 30ml/min)
Cirrhosis or severe liver failure (factor V \< 50%)
Prognosis threatened within 6 months
Circumstances that may impair judgment or understanding of the information given to the patient
Malabsorption syndromes
The following laboratory criteria:
* Serum ASAT,ALAT \> 5 x upper limit of normal (ULN)
* Thrombocytopenia with platelet count \< 50.000/ml
