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Multi-modality MRI Study on Effect to Collateral Circulation and Blood Perfusion of Acute Cerebral Infarction by Human Urinary Kallidinogenase | Clinical Trials | Clareo Health

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Multi-modality MRI Study on Effect to Collateral Circulation and Blood Perfusion of Acute Cerebral Infarction by Human Urinary Kallidinogenase

NCT02259738•XuanwuH 2

View on ClinicalTrials.gov

Summary

Human urinary kallidinogenase can promote the establishment of collateral circulation in the ischemic penumbra due to the stenosis or occlusion of middle cerebral artery and then increase the perfusion.

Detailed Description

Patients with acute ischemic stroke will be given human urinary kallidinogenase .Then we will estimate the cerebral collateral circulation in ischemic regions and final infarct volume, comparing with traditional therapy such as Shuxuening injection, which will provide new evidence for the treatment of ischemic stroke. Perfusion Weighted Imaging(PWI) could be a method to reflect the infarction center and low perfusion of tissue.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age:greater than or equal to 18 years old and less than or equal to 70 years old;
•Time of onset is less than 7 days;
•Acute cerebral infarction due to the stenosis or occlusion of middle cerebral artery diagnosed by CT or MRI;
•The National Institute of Health Stroke Scale(NIHSS) score is 4 to 20;
•Excluding intracranial hemorrhage using CT or MRI.

Exclusion Criteria

•The NIHSS score is less than or equal to 3;
•Patients with cerebral aneurysm, cerebral hemorrhage, brain tumor, brain contusion and laceration of brain and other diseases;
•Intracranial hemorrhage displaying by CT or MRI; Cardiac insufficiency;
•Cardiac insufficiency;
•Chronic liver disease(A/G inversion),elevated alanine aminotransferase(ALT)(more than 1.5 times the normal value);
•Increased serum creatinine(more than 1.5 times the normal value);
•Poorly controlled diabetes;
•Recently suffered from hemorrhagic disease or bleeding tendency;
•Recent use of angiotensin-converting enzyme inhibitor (ACEI) drugs;
•Allergic constitution and had a variety of drug allergy history;
+1 more criteria

Locations (1)

Department of Neurolgy,Xuanwu Hospital of Capital Medical University

Beijing, Beijing Municipality, China

Key Dates

Start Date

January 1, 2013

Primary Completion Date

June 1, 2014

Completion Date

June 1, 2014

Last Updated

October 8, 2014

Enrollment

120

ACTUAL participants

Conditions

Cerebral Infarction

Interventions

Human Urinary Kallidinogenase

DRUG

Shuxuening injection

DRUG

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Cerebral InfarctionStenosis Artery

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 8, 2014Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Multi-modality MRI Study on Effect to Collateral Circulation and Blood Perfusion of Acute Cerebral Infarction by Human Urinary Kallidinogenase

Inclusion Criteria

Exclusion Criteria

The Effect and Safety of Combined Anti-platelet Treatment in Acute Ischemic Stroke Due to Large Artery Atherosclerosis

Observation of the Therapeutic Effect of Fire Needle on Upper Limb Function in Stroke Patients

Traditional Chinese Medicine Intervention for Ischemic Cerebrovascular Disease and Diabetes Mellitus: An Efficacy Comparative Study

The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ACI) in the Treatment of Acute Cerebral Infarction

The Application of Kinesio Taping Technique in the Early Upper Limb Functional Activities Induction of Hemiplegic Patients After Stroke

Effects of Armeo Power Robot Therapy on Upper Limb Recovery in Hemiplegic Stroke Patients