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Combination Therapy of Cord Blood and G-CSF for Patients With Brain Injury or Neurodegenerative Disorders | Clinical Trials | Clareo Health

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Combination Therapy of Cord Blood and G-CSF for Patients With Brain Injury or Neurodegenerative Disorders

A Pilot Study of Combination Therapy of Allogeneic Umbilical Cord Blood and Granulocyte-colony Stimulating Factor for Patients With Brain Injury or Neurodegenerative Disorders

NCT02236065•MinYoung Kim, M.D.

View on ClinicalTrials.gov

Summary

This open label trial is conducted to investigate the efficacy and safety of the combination therapy of allogeneic umbilical cord blood (UCB) and granulocyte-colony stimulating factor (G-CSF) for patients with brain injury or neurodegenerative disorders.

Detailed Description

Current treatments for brain injury or neurodegenerative disorders are palliative rather than curative. Preclinical and some clinical studies suggest that UCB and G-CSF can be used as restorative approach for such disorders.

Eligibility

Age

19 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Brain injury: onset duration over 12 months, Age: 19 years or over
•Cerebral palsy: spastic, dyskinetic or ataxic, Age: 19 years or over
•Parkinson's disease: modified Hoehn and Yahr stage 2.5, 3, 4, Age: 30 to 75 years
•ALS: definite of possible ALS, progression during the past 6 months, Age: 19 to 65

Exclusion Criteria

•Uncontrolled pulmonary, renal dysfunction at enrollment
•Uncontrolled seizure
•Malignant cancer
•Possibility of hypersensitivity to drugs used in this study
•Contraindication to the study intervention or assessment
•Pregnant or breast feeding women
•Non-compliance with the study visits specified in the protocol

Locations (1)

CHA Bundang Medical Center, CHA University

Seongnam-si, Gyeonggi-do, South Korea

Key Dates

Start Date

August 1, 2014

Primary Completion Date

July 1, 2016

Completion Date

July 1, 2016

Last Updated

October 12, 2017

Enrollment

ACTUAL participants

Conditions

Brain InjuryCerebral PalsyAmyotrophic Lateral SclerosisParkinson's Disease

Interventions

Umbilical cord blood therapy

PROCEDURE

Filgrastim

BIOLOGICAL

Effects of Treadmill Training and Whole-body Vibration in Children With Cerebral Palsy

NCT04630392

Cerebral Palsy

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RECRUITINGPHASE3

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

NCT04521881

Traumatic Brain Injury

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RECRUITING

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 12, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Combination Therapy of Cord Blood and G-CSF for Patients With Brain Injury or Neurodegenerative Disorders

Inclusion Criteria

Exclusion Criteria

Effects of Treadmill Training and Whole-body Vibration in Children With Cerebral Palsy

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

Hemodynamic ABI Monitor

Multimodal, Enriched Environment for Rehabilitation in Chronic Traumatic Brain Injury

The EXOPULSE Study - a Database for Routine Follow-up of Clinical Outcomes