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The Effect of Low-frequency rTMS on Motor Function in PD Patients With Freezing of Gait | Clinical Trials | Clareo Health

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The Effect of Low-frequency rTMS on Motor Function in PD Patients With Freezing of Gait

The Effect of Low-frequency Repetitive Transcranial Magnetic Stimulation on Motor Function in Patients With Parkinson's Disease (PD) With Freezing of Gait (FOG).

NCT02221544•Tel-Aviv Sourasky Medical Center

View on ClinicalTrials.gov

Summary

This study is a double blind comparative study examining the effectiveness of the rTMS treatment on Freezing of Gait (FOG) phenomenon in patients with Parkinson's disease. We hypothesize that treatment using rTMS stimulation on frontal lobe areas will improve gait quality and decrease the frequency of FOG in patients with Parkinson's disease.

Detailed Description

A course of low-frequency repetitive transcranial magnetic stimulation (rTMS) delivered over the supplementary motor area (SMA) improves motor symptoms in patients with Parkinson's disease (PD). The present study is a comparative study that examines the effectiveness of rTMS treatment technique Freezing of Gait (FOG) phenomenon in Parkinson's disease patients. We hypothesize that treatment using rTMS stimulation on frontal areas will decreasing frequency of FOGs in patients with Parkinson's disease and improve gait quality and quality of life.

Eligibility

Age

50 - 89 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Idiopathic Parkinson's disease (PD), as diagnosed by a neurologist.
•2. The mini-mental state examination questionnaire score above 24 points.
•3. Suffer from a disabling phenomenon called Freezing of Gait (FoG) (Freezing Of Gait questionnaire score\> = 10)
•4. Negative responses to the Preliminary Safety Magnetic Stimulation Treatment questionnaire.

Exclusion Criteria

•1. Other neurological or psychiatric disorders.
•2. Severe personality disorder.
•3. High Blood Pressure.
•4. History of epilepsy, seizures or convulsions.
•5. History of epilepsy or convulsions in first-degree relatives.
•6. History of head injury or stroke.
•7. Metal remains of the skull or inside the brain (outside the oral cavity).
•8. Surgeries including metallic implants or known history of metal particles in the eye, pacemakers, hearing devices transplantation, or medical pumps.
•9. Current history of migraines for the last six months.
•10. A history of drug or alcohol abuse
+1 more criteria

Locations (1)

Tel Aviv Sourasky Medical Center

Tel Aviv, Israel

Key Dates

Start Date

September 1, 2014

Primary Completion Date

December 1, 2015

Completion Date

December 1, 2016

Last Updated

August 20, 2014

Enrollment

ESTIMATED participants

Conditions

Parkinson's Disease

Interventions

Low-frequency repetitive Transcranial Magnetic Stimulation

DEVICE

rTMS maintenance

DEVICE

Sham

DEVICE

Sham maintenance

DEVICE

Contacts

Nir Giladi, MD

CONTACT

972-3-6974790 nirg@tlvmc.gov.il

Anat Mirelman, PhD

CONTACT

972-3-6974958 anatmi@tlvmc.gov.il

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 20, 2014Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Effect of Low-frequency rTMS on Motor Function in PD Patients With Freezing of Gait

Inclusion Criteria

Exclusion Criteria

Research Into the Safety of a New Agent (VT-5006) in People With and Without Parkinson's Disease

Deep Brain Stimulation Therapy in Movement Disorders

Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) China Study

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

SAD Study in Patients With Parkinson's Disease and Motor Fluctuations