Severe symptomatic hyponatremia requiring acute treatment

Severe renal impairment upon admission (creatinine clearance \< 20 mL/min)

Renal replacement therapy dependent, or requiring upon admission

Acute coronary syndrome on admission

Requires or has a mechanical circulatory support device

Evidence of cardiogenic shock requiring intravenous vasopressors

Pregnancy

Patient requiring concomitant use of strong CYP3A4 inhibitors (clarithromycin, ketoconazole, itraconazole, ritonavir, indinavir, nelfinavir, saquinavir, nefazodone, and telithromycin)

Aquaresis Utility for Hyponatremic Acute Heart Failure Study

What this study is about