Finding studies
Finding studies
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Quanshun Wang, Dr.
CONTACT
Lead
Chinese PLA General Hospital
PRIMARY OBJECTIVES: I. Determine the safety and efficacy of the chimeric antigen receptor T cells transduced with the anti-CD19 (cluster of differentiation antigen 19 ) vector (referred to as CART-19 cells) in elderly patients with MCL. II. Determine duration of in vivo survival of CART-19 cells. RT-PCR (reverse transcription polymerase chain reaction) analysis of whole blood will be used to detect and quantify survival of CART-19 TCR (T-cell receptor) zeta:CD137 and TCR zeta cells over time. SECONDARY OBJECTIVES: For patients with detectable disease, measure anti-tumor response due to CART-19 cell infusions. Estimate relative trafficking of CART-19 cells to tumor in bone marrow and lymph nodes. Determine if cellular or humoral host immunity develops against the murine anti-CD19, and assess correlation with loss of detectable CART-19 (loss of engraftment).
Age
50–80
Sex
ALL
Healthy volunteers
Not accepted