RCT of Methotrexate Added to Treatment As Usual in Schizophrenia

Inclusion Criteria

• •Signed informed consent, indicating that the subject understood the purpose of and procedures required for the study, before the initiation of any study specific procedures
• •Aged 18 to 35 years
• •Diagnostic and Statistical Manual-IV (DSM-IV) diagnosed first episode psychosis, schizophrenia, schizoaffective disorder, psychosis not otherwise specified or schizophreniform disorder.
• •First episode (within first 5 years of diagnosis)
• •Competent and willing to give informed consent
• •Medication remained stable 4 weeks prior to baseline.
• •Able to take oral medication and likely to complete the required evaluations.
• •Female participants of child bearing capability must be willing to use adequate contraceptives for the duration of the study, and, willing to have a pregnancy test pre treatment and at ten weekly intervals while on study medication.
• •1. Adequate contraception is defined as use of contraceptive double barrier system (i.e. condom and spermicide) or contraceptive implant, oral contraceptive or injected depot contraceptive plus other form of contraceptive i.e. condom. Females will be considered incapable of child bearing if they are one year post-menopausal or irreversibly surgically sterilised.
• •Failure to perform screening or baseline examinations
• +7 more criteria