Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade Glioma That Can Be Removed By Surgery

Inclusion Criteria

• •Imaging evaluations necessary to establish eligibility for study entry must be done within three (3) weeks prior to registration; all other evaluations necessary to establish eligibility for study entry must be done within two (2) weeks prior to registration; in the event that the patient's condition deteriorates (performance score \< 60) within 48 hours prior to the injection the patient is no longer eligible to receive HSV1716 injection
• •* An intraoperative MRI upon resection will confirm the distance of the planned injection sites from the ventricular system prior to the HSV1716 injection; intra-operatively, the neurosurgeon may decide to not inject the HSV1716 or may revise the sites of HSV1716 injection if injection cannot be guaranteed \>= 1 cm from the ventricular system; patient will removed from the study if there are not sufficient areas in the tumor cavity to guarantee injection of HSV1716 \>= 1 cm from the ventricular system
• •Patients must have received prior therapy other than surgery and must have fully recovered from the acute treatment related toxicities of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study
• •Patients must have received their last dose of known myelosuppressive anticancer chemotherapy at least three (3) weeks prior to study registration treatment or at least six (6) weeks if nitrosourea
• •Investigational/Biologic agent:
• •* Biologic or investigational agent (anti-neoplastic): Patient must have recovered from any acute toxicity potentially related to the agent and received their last dose of the investigational or biologic agent \>= 7 days prior to study registration
• •* For agents that have known adverse events occurring beyond 7 days after administration, this period must be extended beyond the time during which adverse events are known to occur
• •* Monoclonal antibody treatment: At least three half-lives must have elapsed prior to registration; Note: A list of the half-lives of commonly used monoclonal antibodies is available on the Pediatric Brain Tumor Consortium (PBTC) webpage under Generic Forms and Templates
• •Patients must have had their last fraction of:
• •* Craniospinal irradiation (\> 24 Gray \[Gy\]) or total body irradiation \> 3 months prior to registration
• •* Focal irradiation to symptomatic metastatic sites \> 4 weeks prior to registration
• •* Local palliative external beam radiation therapy (XRT) (small port) \>= 4 weeks
• •* If prior total-body irradiation (TBI), craniospinal XRT or if \>= 50% radiation of pelvis \>= 6 months must have elapsed
• •* If other substantial bone marrow (BM) radiation \>= 6 weeks must have elapsed
• •Patient must be:
• •* \>= 6 months since allogeneic bone marrow transplant prior to registration
• •* Stem cell transplant or rescue without TBI: No evidence of active graft vs. host disease and \>= 3 months must have elapsed since transplant
• •Karnofsky performance scale (KPS for \> 16 years of age) or Lansky performance score (LPS for =\< 16 years of age) assessed within two weeks of registration must be \>= 60
• •Hemoglobin: \>= 10 g/dl
• •Absolute neutrophil count: \>= 1000/mm\^3
• •Platelets: \>= 100,000/mm\^3 (transfusion independent defined as not receiving platelet transfusions within 7 days prior to registration)
• •Total bilirubin: \< 1.5 x upper limit of institutional normal for age
• •Alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]): =\< 2.5 × institutional upper limit of normal
• •Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min/1.73 m\^2 or a serum creatinine based on age and gender as follows:
• •* Age 10 to \< 13 years: maximum serum creatinine (mg/dL): 1.2 for males and 1.2 for females
• •* Age 13 to \< 16 years: maximum serum creatinine (mg/dL): 1.5 for males and 1.4 for females
• •* Age \>= 16 years: maximum serum creatinine (mg/dL): 1.7 for males and 1.4 for females
• •Albumin \>= 2.5 g/dL
• •Partial thromboplastin time (PTT) \< 1.2 X institutional upper limits of normal
• •Patients with neurological deficits should have deficits that are stable for a minimum of 1 week prior to registration; this is to be documented at baseline
• •Patients with central nervous system (CNS) tumors who are receiving dexamethasone must have been on a stable or decreasing dose of dexamethasone for the 7 days prior to enrollment
• •Growth factors that support platelet or white cell number or function must not have been administered within the past 7 days; growth factors include: GCSF (filgrastim), PEG-GCSF (Neulasta), GM-CSF (sargramostim) and erythropoietin
• •Documented evidence of negative tests for the presence of hepatitis B surface antigen, hepatitis C antibody, and human immunodeficiency virus (HIV)1/2 antibodies within the three months preceding study entry; subjects who do not have such evidence must undergo appropriate testing prior to virus administration; HIV-positive patients on combination antiretroviral therapy are ineligible
• •Female patients of childbearing potential must have a negative serum or urine pregnancy test at the time of enrollment
• •Ability to understand and the willingness to sign a written informed consent document according to institutional guidelines