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Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery | Clinical Trials | Clareo Health

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Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery

NCT01881646•Karolinska University Hospital

Summary

The main purpose of this study is to assess the induction of neuroinflammation in brain regions of interest for learning and memory in adult patients undergoing urological surgery under general anesthesia

Detailed Description

The investigators aim to study immune cell activation as a biomarker for neuroinflammation using the cell specific \[11C\]PBR28 probe as detected by PET imaging techniques.

Eligibility

Age

60 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Patients 60-75 years of age. American Society for Anesthesiologist' criteria (ASA) physical status I-III
•2. Lower abdominal surgery (hysterectomy/prostatectomy) under general anaesthesia
•3. Obtained consent within 3 months before execution of the study.

Exclusion Criteria

•1. Patient's refusal to participate in the trial
•2. Ongoing smoking, snuff or other nicotine compound treatment
•3. Disabling neuropsychiatrical disorder (a Mini mental State Examination (MMSE) score ≤ 24, diagnosis of dementia, Mb Alzheimer, Mb Parkinson, schizophrenia, or mental depression) or other signs of significant cognitive decline.
•4. History of stroke with neurological sequelae
•5. Surgical procedure scheduled for regional anaesthesia.
•6. Severe cardia and/or renal and/or hepatic impairment.
•7. Coagulopathy.
•8. Terminal phase of a chronic disease.
•9. Patient on steroidal or non-steroidal anti-inflammatory drugs.
•10. Admission B-Glucose \> 15 mmol/litre or poorly controlled diabetes mellitus.
+2 more criteria

Key Dates

Start Date

June 1, 2013

Primary Completion Date

February 1, 2016

Completion Date

February 1, 2016

Last Updated

January 11, 2017

Enrollment

ACTUAL participants

Conditions

AnesthesiaSurgeryNeurogenic InflammationCognitive Disorders

Interventions

Positron emission tomography (PET) using [11C]PBR28

RADIATION

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RECRUITING

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 11, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery

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