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Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit | Clinical Trials | Clareo Health

COMPLETEDEARLY_PHASE1

Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit

Pilot Study of the Effects of Inhaled Antibiotic on Bacterial Resistance

NCT01878643•Stony Brook University

Summary

The purpose of this study was : * to determine the effect of inhaled antibiotics on airway bacteria in ventilated patients * to determine the effect of inhaled antibiotics on respiratory infection

Detailed Description

Double-blind randomized placebo controlled study examining the effect of aerosolized antibiotics on respiratory infection signs and symptoms and on bacterial eradication and resistance. Systemic antibiotics are administered by the responsible physician

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•be on mechanical ventilation greater than 3 days
•greater than or equal to 18 years and survival greater than 14 days
•organisms on Gram stain with increasing purulent secretions

Exclusion Criteria

•pregnancy
•allergy to drugs administered

Locations (1)

University Hospital Medical Center

Stony Brook, New York, United States

Key Dates

Start Date

December 1, 2001

Primary Completion Date

December 1, 2002

Completion Date

December 1, 2002

Last Updated

June 17, 2013

Enrollment

ACTUAL participants

Conditions

Respiratory InfectionBacterial ResistanceRespiratory Failure

Interventions

vancomycin or gentamicin

DRUG

Placebo

DRUG

Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications

NCT07186933

Postoperative Pulmonary AtelectasisPostoperative Pulmonary Complications+8 more

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RECRUITINGNA

Effectiveness and Implementation of a National Guideline for Acute Respiratory Tract Infections to Reduce Antibiotic Prescribing in Swiss Primary Care

NCT07396428

Acute Respiratory InfectionInfluenza-like Illness

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 17, 2013Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit

Inclusion Criteria

Exclusion Criteria

Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications

Effectiveness and Implementation of a National Guideline for Acute Respiratory Tract Infections to Reduce Antibiotic Prescribing in Swiss Primary Care

Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units

A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score

Global Physiotherapy in ICU Patients With High Risk Extubation Failure

Evaluating the Safety and Performance of the MiniLung Petite Kit in Neonatal and Pediatric Patients With Acute Respiratory and Cardiac Failure