Registry Trial to Determine pCLE Image Interpretation Criteria and Preliminary Accuracy in the Lung

Inclusion Criteria

• •Male or female \> 18 years of age
• •Willing and able to comply with study procedures and provide written informed consent to participate in the study
• •Indeterminate discrete nodule(s) suspicious for cancer scheduled for diagnostic bronchoscopy
• •Newly discovered \&/or prior discovered non classified nodules, hard to define based on CT scan
• •Purpose of bronchoscopy is for diagnosis of lesion(s) - can be solitary pulmonary nodule or multiple lesions
• •All lesion locations are acceptable
• •Any patient undergoing clinically indicated bronchoscopies after lung transplantation
• •Patients post transplant showing clinical signs of acute rejection \>3 weeks; \< 1 year
• •Patient with single or double lung transplant