Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD

Exclusion Criteria

• •Lifetime diagnosis of: psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, mental retardation, or substance/alcohol dependence
• •Current diagnosis of major depressive disorder, Tourette's/Tic Disorder, or substance/alcohol abuse
• •Positive urine screen for illicit drugs
• •Medical or psychiatric conditions that would make participation in the study unsafe
• •Active suicidal ideation
• •Females who are using hormonal birth control
• •Presence of metallic device or dental braces incompatible with MRS
• •Intelligence quotient (IQ) \<80
• •OCD patients with primary symptoms of hoarding (determined by CYBOCS checklist)
• •Current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• •Individuals who are currently receiving Exposure and Response Prevention therapy and are in the acute phase of treatment.
• •Documented history of hypersensitivity or intolerance to tetracycline antibiotics
• •Use of medications that are contra-indicated with minocycline (e.g., concomitant use of antacids, iron, calcium, magnesium, aluminum, zinc salts as they impair minocycline absorption; of anti-coagulant drugs as minocycline has been shown to depress plasma prothrombin activity; of other antibiotics or Accutane due to the rare side effect of pseudotumor cerebri)
• •Inability of participant or parent/guardian to read or understand English