Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Irmandade Santa Casa de Misericórdia de Porto Alegre
With
Novartis
Age
40–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Men and women (neither pregnant nor nursing women) ≥40 years of age, with a history of smoking (\>20 years/pack) and COPD diagnosis according to GOLD criteria.
Post-bronchodilator FEV1 \>50% and \<80%, and FEV1/FVC ≤70% of predicted value.
You may not be if
Hospital admission due to COPD exacerbation or lung infection in the 6 weeks prior to screening, diagnosis of current or previous bronchial asthma, history of allergic rhinitis or other atopic diseases, or peripheral eosinophilia \>400/mm3.
Inability to discontinue the usual bronchodilator therapy prior to initial screening tests, need for continuous oxygen therapy, or arterial oxygen saturation \<85% at rest, or history of adverse reactions to sympathomimetic amines or use of inhaled medication.
Anemia, hypo- or hyperthyroidism, hyperadrenergic conditions, uncontrolled insulin-dependent diabetes mellitus, malignancy, or any disease or condition that limits exercise capacity other than COPD.
History of drug or alcohol abuse, poor adherence to drug treatment, or treatment with any investigational drug in the month before screening.
Patients with ventricular arrhythmia.
Patients with \<80% oxyhemoglobin saturation during exercise testing
