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Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation | Clinical Trials | Clareo Health

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Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation

NCT01616615•Sara Varea

View on ClinicalTrials.gov

Summary

To establish wether a prophylactic intervention from first trimester with low-dose of aspirin improves trophoblastic invasion evaluated at third trimester in women defined as high-risk by abnormal uterine artery Doppler at first trimester

Eligibility

Age

18 - No limit years

Sex

FEMALE

Healthy Volunteers

Inclusion Criteria

•Patients over 18 years old attending for routine ultrasound at first trimester of pregnancy between 11 and 14 weeks of gestation (Crown-to rump length 45-48mm)
•Single gestation
•Mean pulsatility index of the uterine arteries above the 95th percentile for our population

Exclusion Criteria

•Pre-existing hypertension, renal or cardiovascular disease
•previous history of pre-eclampsia
•Pregestational diabetes
•Systemic lupus Erythematosus
•Gastric ulcer
•Acetylsalicylic acid or lactose hypersensitivity
•Bleeding disorders
•Fetal disorders (including chromosomal abnormalities)
•Administration of low molecular weight heparin
•Concomitant treatment with aspirin

Locations (3)

Hospital Clinic of Barcelona

Barcelona, Barcelona, Spain

Institut Dexeus

Barcelona, Barcelona, Spain

Hospital Clínico Lozano Blesa

Zaragoza, Zaragoza, Spain

Key Dates

Start Date

September 1, 2012

Primary Completion Date

April 1, 2015

Completion Date

April 1, 2015

Last Updated

August 18, 2015

Enrollment

190

ACTUAL participants

Conditions

Placental Insufficiency

Interventions

Aspirin

DRUG

placebo

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 18, 2015Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation

Inclusion Criteria

Exclusion Criteria

Speckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth Twin Pregnancies

Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE

PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome

Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia