A Study to Investigate the Tolerability and Effect of Three Single-dose Regimens of BIA 9-1067

Exclusion Criteria

• •Non-idiopathic parkinsonism (atypical parkinsonism, symptomatic parkinsonism, Parkinson-plus syndrome);
• •Treated with levodopa/carbidopa or levodopa/benserazide in a 10:1 ratio, or with levodopa/carbidopa in a controlled-release formulation;
• •Treated with entacapone, tolcapone, neuroleptics, antidepressants (except serotonin-specific reuptake inhibitors or imipramines \[desipramine, imipramine, clomipramine and amitriptyline\]), monoamine oxidase inhibitors (except selegiline up to 10 mg/day in oral formulation or 1.25 mg/day in buccal absorption formulation or rasagiline up to 1 mg/day) or antiemetics (except domperidone) within 4 weeks prior to randomisation;
• •Treated with apomorphine within 7 days prior to randomisation;
• •Treated with any investigational product within 2 months prior to randomisation (or within 5 half-lives, whichever is longer);
• •A psychiatric or any medical condition that might place him/her at increased risk or interfere with assessments;
• •Known hypersensitivity to any of the ingredients of the investigational products;
• •A history of abuse of alcohol, drugs or medications within the last 2 years;
• •A clinically relevant ECG abnormality;
• •A history or current evidence of heart disease, including but not limited to myocardial infarction, angina, congestive heart failure and cardiac arrhythmia;
• •Unstable concomitant disease being treated with changing doses of medication;
• •A history or current evidence of any relevant disease in the context of this study, i.e., with respect to the safety of the subject (e.g., hepatic or renal impairment) or related to the study conditions;
• •A test positive for the human immunodeficiency viruses (HIV) 1 or 2 antibodies, or hepatitis B surface antigen (HBsAg), or hepatitis C antibody (HCVAb);
• •Donated blood or received blood or blood products within the 6 months prior to randomisation;
• •Pregnant, breast-feeding or of childbearing potential;
• •Other condition or circumstance that, in the opinion of the investigator, may compromise the subject's ability to comply with the study protocol.