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Efficacy Study of Ilaprazole to Treat Erosive Esophgitis | Clinical Trials | Clareo Health

COMPLETEDPHASE3

Efficacy Study of Ilaprazole to Treat Erosive Esophgitis

A Phase Ⅲ Multi-center, Randomized, Double-blind, Active-controlled Study to Evaluate the Efficacy and Safety of Ilaprazole (20mg QD) in Adult Patients With Erosive Esophagitis

NCT01509261•Il-Yang Pharm. Co., Ltd.

View on ClinicalTrials.gov

Summary

This study compared Ilaprazole 20mg with lansoprazole 30mg for the healing of erosive esophagitis and resolution of heartburn.

Eligibility

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Subject must have endoscopically confirmed erosive esophagitis as defined by the Los Angeles (LA) Classification Grading System (A-D) within 14 days prior to baseline.
•Episodes of heartburn or regurgitation has experienced during the last 7 days prior to baseline.

Exclusion Criteria

•Coexisting diseases affecting the esophagus (eg, eosinophilic esophagitis, esophageal varices, scleroderma, viral or fungal infection, or esophageal stricture), history of radiation therapy or cryotherapy to the esophagus, caustic or physiochemical trauma such as sclerotherapy to the esophagus. Presence of a Schatzki's ring (a ring of mucosal tissue near the lower esophageal sphincter) or Barrett's esophagus were not exclusionary.
•Current or a history of Zollinger-Ellison syndrome and other acid hypersecretory conditions, or current gastric or duodenal ulcer.
•Known hypersensitivity to any PPI (including lansoprazole, omeprazole, rabeprazole, pantoprazole or esomeprazole), any component of ilaprazole, or Gelusil.
•Cancer (except basal cell carcinoma of the skin) within 5 years prior to screening.

Locations (19)

Local Institution

Seoul, South Korea

Local Institution

Seoul, South Korea

Local Institution

Seoul, South Korea

Local Institution

Seoul, South Korea

Local Institution

Seoul, South Korea

Local Institution

Seoul, South Korea

Local Institution

Seoul, South Korea

Local Institution

Seoul, South Korea

Local Institution

Seoul, South Korea

Local Institution

Seoul, South Korea

Key Dates

Start Date

July 1, 2010

Primary Completion Date

June 1, 2011

Completion Date

June 1, 2011

Last Updated

January 12, 2012

Enrollment

292

ACTUAL participants

Conditions

Erosive EsophagitisGERD

Interventions

Ilaprazole

DRUG

Lansoprazole

DRUG

Alginate vs Sucralfate for GERD Symptomatic Relief

NCT07310927

GERD

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RECRUITINGNA

A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks

NCT06953986

GERD

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RECRUITINGPHASE4

Famotidine and Antacids for Treatment of Dyspepsia

NCT06241183

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 12, 2012Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Efficacy Study of Ilaprazole to Treat Erosive Esophgitis

Inclusion Criteria

Exclusion Criteria

Alginate vs Sucralfate for GERD Symptomatic Relief

A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks

Famotidine and Antacids for Treatment of Dyspepsia

Stretta Versus Conservative Treatment

Gracie Diet for Gastroesophageal Reflux Disease

Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair