Proton Radiation for Chordomas and Chondrosarcomas

Proton Radiation For Chordomas and Chondrosarcomas

NCT01449149•Abramson Cancer Center at Penn Medicine

Summary

The objectives of this study are 1) To evaluate the feasibility and acute side effects of proton therapy for chordomas and chondrosarcomas and 2) To evaluate clinical outcomes and long term side effects of proton beam radiation for treatment of chordomas and chondrosarcomas.

Detailed Description

This trial will be conducted in two phases: a feasibility then a phase II trial. Once feasibility and safety are established in the first 12 pts. the phase II study will begin. Proton therapy at standard doses is not known to improve clinical outcome but will likely reduce fatigue and toxicity.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Histologically confirmed diagnosis of chordoma or chondrosarcoma.
•Patients must have no evidence of metastatic disease based on routine imaging (CT or MRI of the chest/abdomen/pelvis, bone scan, etc.)
•Patients must have an ECOG score equal to or less than 2.
•Age ≥ 18 years.
•Patients must be able to provide informed consent.
•Adequate bone marrow function: WBC ≥ 4000/mm3, platelets ≥ 100, 000mm3
•Women of child-bearing potential as long as she agrees to use a recognized method of birth control (e.g. oral contraceptive , IUD, condoms or other barrier methods etc.) Hysterectomy or menopause must be clinically documented.
•Tumors arising in the skull and spine.

Exclusion Criteria

•Prior or simultaneous malignancies within the past two years (other than cutaneous squamous or basal cell carcinoma, melanoma in situ or thyroid carcinoma)
•Patients with the following histologies are excluded: melanoma , other soft tissue or bony sarcomas, giant cell tumor aneurismal bone cyst or metastatic lesions from other histologies.
•Pregnant women.
•Actively being treated on any other therapeutic research study.
•Tumors arising outside of the CNS.

Locations (1)

Abramson Cancer Center of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Key Dates

Start Date

March 1, 2010

Primary Completion Date

July 1, 2025

Completion Date

September 4, 2025

Last Updated

December 5, 2025

Enrollment

ACTUAL participants

Conditions

ChordomasChondrosarcomas

Interventions

Proton Therapy

RADIATION

Proton Therapy for Chordomas and/or Chondrosarcomas

NCT00797602

ChordomasChondrosarcomas

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 5, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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