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COMPLETEDPHASE1

The Influence of GINkGo Biloba on the Pharmacokinetics of the UGT Substrate raltEgraviR (GINGER)

NCT01246804•Radboud University Medical Center

Summary

The objective of this study is to evaluate the effect of ginkgo biloba (steady state) on the pharmacokinetics of a single dose of the UGT-substrate raltegravir. Furthermore the safety profile of the combination is studied.

Detailed Description

Ginkgo biloba is an alternative medicine that is popular among HIV-infected patients because if its claimed positive effects on memory, concentration and depression. Alternative medicine can cause drug-drug interactions with regular HIV-medication. Raltegravir is a newly developed HIV integrase inhibitor. It is metabolized in the liver by UGT1A1 and therefore its pharmacokinetic profile can be influenced by inhibitors or inducers of UGT1A1. So far there are no data of the potential effect of ginkgo biloba on glucuronidation in vivo. The current study is designed to evaluate the potential inductive effect of ginkgo biloba on the pharmacokinetics of raltegravir and the safety profile when used in combination.

Eligibility

Age

18 - 55 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Subject is at least 18 and not older than 55 years at screening.
•Subject does not smoke more than 10 cigarettes, 2 cigars, or 2 pipes per day for at least 3 months prior to the first dosing
•Subject has a Quetelet Index (Body Mass Index) of 18 to 30 kg/m2, extremes included.
•Subject is able and willing to sign the Informed Consent Form prior to screening evaluations.
•Subject is in good age-appropriate health condition as established by medical history, physical examination, electrocardiography, results of biochemistry, haematology and urinalysis testing within 4 weeks prior to Day 1. Results of biochemistry, haematology and urinalysis testing should be within the laboratory's reference ranges. If laboratory results are not within the reference ranges, the subject is included on condition that the Investigator judges that the deviations are not clinically relevant. This should be clearly recorded.
•Subject has a normal blood pressure and pulse rate, according to the Investigator's judgement.

Exclusion Criteria

•Documented history of sensitivity/idiosyncrasy to medicinal products or excipients.
•Positive HIV test.
•Positive hepatitis B or C test.
•Pregnant female (as confirmed by an HCG test performed less than 4 weeks before Day 1) or breast-feeding female. Female subjects of childbearing potential without adequate contraception, e.g. hysterectomy, bilateral tubal ligation, (non-hormonal) intrauterine device, total abstinence, double barrier methods, or two years post-menopausal. They must agree to take precautions in order to prevent a pregnancy throughout the entire conduct of the trial.
•Therapy with any drug (for two weeks preceding dosing), except for paracetamol.
•Relevant history or presence of pulmonary disorders (especially COPD), cardiovascular disorders, neurological disorders (especially seizures and migraine), psychiatric disorders, gastro-intestinal disorders, renal and hepatic disorders, hormonal disorders (especially diabetes mellitus), coagulation disorders.
•Relevant history or current condition that might interfere with drug absorption, distribution, metabolism or excretion.
•History of or current abuse of drugs, alcohol or solvents.
•Inability to understand the nature and extent of the trial and the procedures required.
•Participation in a drug trial within 60 days prior to Day 1.
+2 more criteria

Locations (1)

CRCN, Radboud University Medical Centre

Nijmegen, Netherlands

Key Dates

Start Date

November 1, 2010

Primary Completion Date

March 1, 2011

Completion Date

May 1, 2011

Last Updated

November 30, 2020

Enrollment

ACTUAL participants

Conditions

HIV InfectionsDepressionMild Cognitive Impairment

Interventions

raltegravir single dose

DRUG

ginkgo biloba multiple dose

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 30, 2020Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Influence of GINkGo Biloba on the Pharmacokinetics of the UGT Substrate raltEgraviR (GINGER)

Inclusion Criteria

Exclusion Criteria

ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

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