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Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis | Clinical Trials | Clareo Health

COMPLETEDNA

Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis

NCT01246596•Centre Hospitalier Universitaire de Nice

View on ClinicalTrials.gov

Summary

The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•10 patients affected by chronic periodontitis
•10 patients affected by aggressive periodontitis
•10 healthy patients (orthodontics extraction)
•Subject who have read and understood the information note relative under investigation and who have signed the informed consent
•major patient

Exclusion Criteria

•Patient with no contre-indication to periodontal treatment
•Patient with serious blood disease
•Patient who exhibits systemic condition incompatible with realization of the study
•Patient treated with oral retinoids, bisphosphonates, oral anticoagulants and anticonvulsivants
•Patient who presents a buccal carcinoma treated with radiotherapy
•Patient who have received during the past 6 months: anti-inflammatory drugs, anti-cancerous or immunosuppressive chemiotherapy
•Patient who presents a linguistic or psychic incapacity to understand information

Locations (1)

Dr Severine VINCENT

Nice, France

Key Dates

Start Date

January 1, 2011

Primary Completion Date

May 5, 2014

Completion Date

May 5, 2014

Last Updated

November 13, 2023

Enrollment

ACTUAL participants

Conditions

Chronic PeriodontitisAggressive PeriodontitisPresence / Absence of EBV

Interventions

dental root planing

PROCEDURE

dental root planing

PROCEDURE

dental root planing

PROCEDURE

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 13, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis

Inclusion Criteria

Exclusion Criteria

Bovine Bone With or Without Concentrated Growth Factor in the Treatment of Chronic Periodontitis

Evaluation of Acacia Catechu and Low-Level Laser in the Treatmentof Stage II Periodontitis

Treatment of Periodontitis With Er:YAG Laser

Apoptosis Markers in Aggressive Periodontitis

Effect of Azithromycin on Failure Proportion of Severe Periodontitis Non-surgical Treatment

NSPT on Calprotectin and Periostin Levels