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Surgical Sympathetic Blockade in Heart Failure | Clinical Trials | Clareo Health

COMPLETEDPHASE1

Surgical Sympathetic Blockade in Heart Failure

Left Cervico-Thoracic Sympathetic Blockade by Clipping in Systolic Heart Failure: A Randomised Controlled Trial

NCT01224899•University of Sao Paulo

Summary

The investigators sought to evaluate the feasibility and safety of surgical sympathetic blockade in systolic heart failure patients and secondary to assess its cardiovascular consequences.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•chronic heart failure (at least 1 month of symptoms onset)
•NYHA functional class II or III
•LV ejection fraction 40% or lower
•resting heart rate higher than 65 bpm
•either maximum beta-blocker therapy according to guidelines or no beta-blocker use for intolerance.

Exclusion Criteria

•NYHA functional class I or IV
•cardiogenic shock
•resting heart rate ≤ 65 bpm
•systolic blood pressure \< 90 mmHg
•sustained ventricular tachycardia
•eligibility to other surgical procedures
•procedure-limiting comorbidity
•presence of ICD or pacemaker
•valvar, chagasic or congenital cardiomyopathy
•age \> 70 years
+5 more criteria

Locations (1)

Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo, São Paulo, Brazil

Key Dates

Start Date

December 1, 2006

Primary Completion Date

November 1, 2009

Completion Date

July 1, 2010

Last Updated

October 20, 2010

Enrollment

ACTUAL participants

Conditions

Systolic Heart FailureBeta-blockers IntoleranceBeta-blockers Resistance

Interventions

Left cervico-thoracic sympathetic blockade

PROCEDURE

A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure

NCT03984591

Systolic Heart Failure

View study

COMPLETEDNA

Imaging Study of Allocation of Pacing Targets in Cardiac Resynchronization Therapy

NCT01640769

Systolic Heart FailureDysynchrony+3 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 20, 2010Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Surgical Sympathetic Blockade in Heart Failure

Inclusion Criteria

Exclusion Criteria

A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure

Imaging Study of Allocation of Pacing Targets in Cardiac Resynchronization Therapy

Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy

A Pilot Trial of Patient Decision Aids for Implantable Cardioverter-Defibrillators (ICDs)

Renal Artery Denervation in Chronic Heart Failure Study

Effect of Nitrate-rich Beetroot Juice on Exercise Performance in Heart Failure Patients