Primary DSM-IV diagnosis of Schizophrenia based on SCID for schizophrenia and confirmed by two senior psychiatrists.
Patients who scored "moderate" (4) or higher on at least three of seven positive items in PANSS
Initiated on treatment with atypical anti-psychotic medication.
Capable and willing to provide informed consent
Able to adhere to the treatment schedule
Able to read, hear, write and speak the local language.
Has signed a written informed consent to participate in the study
You may not be if
Patients with acute, unstable, significant, or untreated medical illness besides schizophrenia including alcohol and drug dependence, or depression.
Current suicidal ideation or history of a suicide attempt in the past 3 years
Known or suspected pregnancy or women of childbearing potential and not using a medically accepted form of contraception when engaging in sexual intercourse. or women who are breastfeeding
Subjects who were taking a known contraindication to minocycline treatment.
Subjects who had received treatment with minocycline or β-lactam antibiotics in the preceding half year before study entry.
Subjects who were under compulsory hospitalization.
Clareo Health | Minocycline as an Adjunctive Therapy for Schizophrenia: a Randomized Controlled Study
